NFATc3 regulates BK channel function in murine urinary bladder smooth muscle
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چکیده
منابع مشابه
NFATc3 regulates BK channel function in murine urinary bladder smooth muscle.
The nuclear factor of activated T-cells (NFAT) is a Ca(2+)-dependent transcription factor that has been reported to regulate the expression of smooth muscle contractile proteins and ion channels. Here we report that large conductance Ca(2+)-sensitive potassium (BK) channels and voltage-gated K(+) (K(V)) channels may be regulatory targets of NFATc3 in urinary bladder smooth muscle (UBSM). UBSM m...
متن کاملBK channel-mediated relaxation of urinary bladder smooth muscle: a novel paradigm for phosphodiesterase type 4 regulation of bladder function.
Elevation of intracellular cAMP and activation of protein kinase A (PKA) lead to activation of large conductance voltage- and Ca(2+)-activated K(+) (BK) channels, thus attenuation of detrusor smooth muscle (DSM) contractility. In this study, we investigated the mechanism by which pharmacological inhibition of cAMP-specific phosphodiesterase 4 (PDE4) with rolipram or Ro-20-1724 (C(15)H(22)N(2)O(...
متن کاملCentral role of the BK channel in urinary bladder smooth muscle physiology and pathophysiology
Petkov GV. Central role of the BK channel in urinary bladder smooth muscle physiology and pathophysiology. Am J Physiol Regul Integr Comp Physiol 307: R571– R584, 2014. First published July 2, 2014; doi:10.1152/ajpregu.00142.2014.—The physiological functions of the urinary bladder are to store and periodically expel urine. These tasks are facilitated by the contraction and relaxation of the uri...
متن کاملRe: Central Role of the BK Channel in Urinary Bladder Smooth Muscle Physiology and Pathophysiology.
The physiological functions of the urinary bladder are to store and periodically expel urine. These tasks are facilitated by the contraction and relaxation of the urinary bladder smooth muscle (UBSM), also known as detrusor smooth muscle, which comprises the bladder wall. The large-conductance voltage- and Ca(2+)-activated K(+) (BK, BKCa, MaxiK, Slo1, or KCa1.1) channel is highly expressed in U...
متن کاملBK channel activation by NS11021 decreases excitability and contractility of urinary bladder smooth muscle.
Large-conductance Ca(2+)-activated potassium (BK) channels play an important role in regulating the function and activity of urinary bladder smooth muscle (UBSM), and the loss of BK channel function has been shown to increase UBSM excitability and contractility. However, it is not known whether activation of BK channels has the converse effect of reducing UBSM excitability and contractility. He...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Cell Physiology
سال: 2008
ISSN: 0363-6143,1522-1563
DOI: 10.1152/ajpcell.00435.2007